FoxO1 Regulates Multiple Metabolic Pathways in the Liver
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چکیده
منابع مشابه
FoxO1 Regulates Multiple Metabolic Pathways in the Liver
From the Departments of Medicine and Physiology and Biophysics, University of Illinois College of Medicine, Chicago, Illinois 60612, the Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612, the Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, the Department of Pharmacology, University of Colorado Health Science Center, Aurora, Colorado 80045, the **Re...
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FoxO transcription factors are important targets of insulin action. To better understand the role of FoxO proteins in the liver, we created transgenic mice expressing constitutively active FoxO1 in the liver using the alpha1-antitrypsin promoter. Fasting glucose levels are increased, and glucose tolerance is impaired in transgenic (TGN) versus wild type (WT) mice. Interestingly, fasting triglyc...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m600272200